I am sorry, I feel like I'm putting a stick in the ants nest here. There's has been a lot of scientific research on how psilocybin found in "magic mushrooms" can help treat clinical depression by changing the structure of the brain. In a similar way long term meditation changes the brain waves. I believe though that Zen is much more than Kensho, or a "trip into the nature of the universe". Hakuin wrote a bit about wasted Satoris, because some masters got "Zen sickness" and couldn't realise the Way in ordinary daily life.
Gassho
Sat
Gassho
Sat
with a bit of this and that, although never to the point that it took over my life or seemed to cause me any harm. I value the experiences, which were lessons on the power of the mind. I am not opposed to some experimentation at certain points in life. But, as you say, that is not Zen practice, which is also "mind eye opening," but also totally down to earth and ordinary in our day to day living. We do not need any mind altering substances apart from Zazen and our practice.
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