I am sorry, I feel like I'm putting a stick in the ants nest here. There's has been a lot of scientific research on how psilocybin found in "magic mushrooms" can help treat clinical depression by changing the structure of the brain. In a similar way long term meditation changes the brain waves. I believe though that Zen is much more than Kensho, or a "trip into the nature of the universe". Hakuin wrote a bit about wasted Satoris, because some masters got "Zen sickness" and couldn't realise the Way in ordinary daily life.
Gassho
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Gassho
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